Diagnostic value of neutrophil CD64, procalcitonin, and interleukin-6 in sepsis: a meta-analysis

Abstract Background The aim of the study was to conduct a meta-analysis evaluate accuracy neutrophil CD64, procalcitonin (PCT), and interleukin-6 (IL-6) as markers for diagnosis sepsis in adult patients. Methods Various databases were searched collect published studies on patients using PCT, IL-6 levels. Utilizing Stata SE 15.0 software, forest plots area under summary receiver operating characteristic curves drawn. pooled sensitivity, specificity, positive likelihood ratio, negative diagnostic odds curve (AUC) calculated. Results Fifty-four articles included study. AUC CD64 0.88 (95% confidence interval [CI], 0.81–0.92), CI, 0.83–0.91), 0.94 0.91–0.96), respectively. PCT 0.82 0.78–0.85), 0.78 0.74–0.82), 0.87 0.83–0.89), Subgroup analysis showed that intensive care unit (ICU) 0.86 0.83–0.89) non-ICU 0.78–0.85). 0.72 0.65–0.78), 0.70 0.62–0.76), 0.77 0.73–0.80), Conclusions Of three biomarkers studied, highest value sepsis, followed by IL-6. On other hand, better potential with severe conditions compared non-severe conditions.